Because I only try new saddles during years that end with a number, I put yet another new perch under my bum in 2013, the Terry Fly, in its less-expensive chromoly railway:
My first impression of the Fly (after setting it up level like I do with my other saddles) was a definitive "uh, no thank you." Without getting too graphic, let's just say that it almost immediately caused the (ahem) "condition" that it purports to cure. And lo, my nether regions were greatly displeased.
I am nothing if not stubborn, however, so I did a bit of reading on the Internets and learned that many folks get on better with the Fly if the nose is angled ever so slightly up. I did exactly that, and presto: Disappearing saddle. Seriously. I didn't give it a second thought from that day forward. Long rides, short rides, rides in Lycra, rides in baggy shorts, rides in jeans (JEANS, for Pete's sake!)... the saddle was simply a non-thing. I think that's why I haven't mentioned it here until now. I forgot about it.
The hole is weird, yes. And I have no idea if it's working any magic with the blood flow in the land down under. Frankly, I don't care. It's just comfortable.
(Interesting side note about the chromoly-rail model: The rails attach to little flexible "bridges" in the back rather than directly to the shell. It's hard to say whether that adds any comfort, though it should in theory. It does, however, provide a couple mounting points for the straps of a traditional saddlebag if you're so inclined.)
The Obligatory Disclaimer: I bought my saddle with pennies I saved from my paper route, and was not bribed or coerced to say nice things about it. If you go to that Amazon link and buy one, however, I'll make a cut on the deal. So there's that.